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Lack of neuroprotection after systemic administration of the soluble TNF inhibitor XPro1595 in an rAAV6-α-Syn+PFFs-induced rat model for Parkinson’s disease

2024-10-23

Abstract excerpt

Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration, α-Synuclein (α-Syn) pathology, and inflammation. Microglia in the substantia nigra pars compacta (SNpc) upregulate major histocompatibility complex class II (MHCII), and variants in genes encoding MHCII affect PD risk. Additionally, elevated TNF levels and α-Syn-reactive T cells in circulation suggest a strong link between innate and adap...

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Literature Corpus work
307093bb-d3d0-5ce5-b345-e8de3d0d0b2f
DOI
10.1101/2024.10.23.619575
Open publication

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Lack of neuroprotection after systemic administration of the soluble TNF inhibitor XPro1595 in an rAAV6-α-Syn+PFFs-induced rat model for Parkinson’s diseaseDOI 10.1101/2024.10.23.619575
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