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MHC class II transactivator effects on local and systemic immune responses in an α-synuclein seeded rat model for Parkinson’s disease

2022-12-03

Abstract excerpt

<h4>BACKGROUND</h4> Parkinson’s disease (PD) is characterized by alpha-synuclein (α-Syn) pathology, neurodegeneration and neuroinflammation. HLA variants associated with PD and α-Syn specific circulating CD4+ T lymphocytes in PD patients highlight the importance of antigen presentation in PD etiology. The class II transactivator (CIITA) is the major regulator of MHCII expression. Reduced Ciita levels significant...

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Literature Corpus work
e462cbac-186c-5f0a-815f-e994042773f4
DOI
10.1101/2022.12.02.518821
Open publication

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MHC class II transactivator effects on local and systemic immune responses in an α-synuclein seeded rat model for Parkinson’s diseaseDOI 10.1101/2022.12.02.518821
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