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Article

Bidirectional 2-sample Mendelian randomization study of the causal relationship between hypothyroidism and cardiovascular diseases.

Medicine - 21 Nov 2025

Chi Jianing, Qiu Sheng, Ma Wenqiang, Yan Guanyu, Xue Yanhua

Abstract excerpt

A bidirectional 2-sample Mendelian randomization (MR) analysis was used to investigate the causal relationship between hypothyroidism and multiple types of cardiovascular diseases (CVDs). Single nucleotide polymorphisms strongly associated with hypothyroidism and 4 CVDs (myocardial infarction, coronary artery disease, heart failure [HF], hypertension) were extracted from genome-wide association study summary data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41305791
DOI: 10.1097/MD.0000000000045889
PMCID: PMC12643746

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