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Article

The causal effects of hypothyroidism on cardiovascular disease: Bidirectional and multivariable Mendelian randomization study.

Journal of diabetes investigation - 1 Mar 2026

Bai Xuan, Sun Mengyi, Han Xu

Abstract excerpt

BACKGROUND: Whether hypothyroidism and cardiovascular disease (CVD) are causally related remains ambiguous. A bidirectional and multivariable two-sample Mendelian Randomization (MR) approach was employed to elucidate these associations. METHODS: All genome-wide association study (GWAS) data were obtained from the IEU Open GWAS project. For the MR estimates, inverse variance weighted (IVW), MR-Egger regression,...

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Cardiovascular Diseases
CAD gene
Genetic Predisposition to Disease
Genome-Wide Association Study
Hypothyroidism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 41555832
DOI: 10.1111/jdi.70237
PMCID: PMC12950919

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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