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Article

Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study.

Cardiovascular therapeutics - 1 Jan 2026

Guo Junchi, Huang Fang, Lu Peihan, Lu Meijuan

Abstract excerpt

Background: Coronary heart disease (CHD) is a leading cause of cardiovascular mortality worldwide, with its pathogenesis being complex and not yet fully understood. The rapid development of genomics, especially in epigenetic research, has provided essential tools for identifying new pathogenic targets. This study is aimed at systematically exploring the molecular mechanisms of CHD using protein quantitative trait...

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Share to Coronary Disease
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Integrin beta Chains

Share to Mendelian Randomization Analysis

Share to Metabolic Networks and Pathways

Share to Multiomics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41509664
DOI: 10.1155/cdr/4885476
PMCID: PMC12776257

Genes

ITGB7
CD4
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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