Article

Combination of alpha-synuclein aggregation inhibitor anle138b and ER stress inhibitor AMG PERK 44 increases neuroprotection in Parkinson’s disease organoid model

2026-03-18

Abstract excerpt

Parkinson’s disease (PD) is the second most common neurodegenerative disease, resulting from accumulation of α-synuclein (α-syn) in midbrain dopaminergic neurons and progressive neuronal loss. The most relevant species of α-syn, oligomers, may exert neurotoxicity in a variety of mechanisms. Accumulation of misfolded α-syn in the endoplasmic reticulum (ER) lumen induces ER stress conditions that leads to activation...

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Literature Corpus work: 6c930798-58bb-59bc-a9c7-a8f329cda39a
DOI: 10.64898/2026.03.16.712219

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