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The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy

11 Sept 2021

Abstract excerpt

Accumulation of α-synuclein is a main underlying pathological feature of Parkinson's disease and α-synucleinopathies, for which lowering expression of the α-synuclein gene (SNCA) is a potential therapeutic avenue. Using a cell-based luciferase reporter of SNCA expression we performed a quantitative high-throughput screen of 155,885 compounds and identified A-443654, an inhibitor of the multiple functional kinase...

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PMID: 34520759
DOI: 10.1016/j.jbc.2021.101191

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