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Article

Differential roles of proteasome and autophagy in α-synuclein and E46K oligomer clearance: insight into the modulatory effects of the dopamine metabolite DOPAC.

International journal of biological macromolecules - 1 Feb 2026

Leri Manuela, Trolese Philipp, Inciardi Ilenia, de Laureto Patrizia Polverino, Bucciantini Monica

Abstract excerpt

The build-up of misfolded α-synuclein (Syn) proteins plays a key role in diseases such as Parkinson's disease. Here, we compared the cytotoxicity and intracellular processing of wild-type and E46K mutant Syn aggregates in SH-SY5Y neuroblastoma cells and investigated the modulatory effects of the dopamine metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC). E46K aggregates displayed markedly higher toxicity than...

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PMID: 41539523
DOI: 10.1016/j.ijbiomac.2026.150224

Genes

LAMP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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