Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins.

doi:10.1186/s13024-022-00592-2

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Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins.

Molecular neurodegeneration - 7 Jan 2023

Oatman Stephanie R, Reddy Joseph S, Quicksall Zachary, Carrasquillo Minerva M, Wang Xue, Liu Chia-Chen, Yamazaki Yu, Nguyen Thuy T, Malphrus Kimberly, Heckman Michael, Biswas Kristi, Nho Kwangsik, Baker Matthew, Martens Yuka A, Zhao Na, Kim Jun Pyo, Risacher Shannon L, Rademakers Rosa, Saykin Andrew J, DeTure Michael, Murray Melissa E, Kanekiyo Takahisa, Dickson Dennis W, Bu Guojun, Allen Mariet, Ertekin-Taner Nilüfer

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is neuropathologically characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The main protein components of these hallmarks include Aβ40, Aβ42, tau, phosphor-tau, and APOE. We hypothesize that genetic variants influence the levels and solubility of these AD-related proteins in the brain; identifying these may provide key insights into disease pathogenesis....

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PMID: 36609403
DOI: 10.1186/s13024-022-00592-2
PMCID: PMC9825010

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