Article

SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant transformation

2024-12-10

Abstract excerpt

Squamous cell carcinomas (SCC) are often preceded by potentially malignant precursor lesions, most of which remain benign. The terminal exhaustion phenotypes of effector T-cells and the accumulation of myeloid-derived suppressor cells (MDSC) have been thoroughly characterized in established SCC. However, it is unclear what precancerous lesions harbor a bona fide high risk for malignant transformation and how preca...

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Literature Corpus work: 6c60772c-48ed-57f4-a727-1d398b9c5d71
DOI: 10.1101/2024.12.06.626475

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