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Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes

6 Nov 2018

Abstract excerpt

Abstract There are distinct cell subpopulations in normal epithelial tissue, including stem cells, progenitor cells, and more differentiated cells, all of which have been extensively studied for their susceptibility to tumorigenesis. However, normal cells usually have to progress through a precancerous lesion state before becoming a full-blown tumor. Precancerous early lesions are heterogeneous, and the cell...

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PMID: 30401712
DOI: 10.1158/0008-5472.can-18-1087

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