Article
Precancerous stem cells have the potential for both benign and malignant differentiation.
PloS one - 14 Mar 2007
Chen Li, Shen Rulong, Ye Yin, Pu Xin-An, Liu Xingluo, Duan Wenrui, Wen Jing, Zimmerer Jason, Wang Ying, Liu Yan, Lasky Larry C, Heerema Nyla A, Perrotti Danilo, Ozato Keiko, Kuramochi-Miyagawa Satomi, Nakano Toru, Yates Allen J, Carson William E, Lin Haifan, Barsky Sanford H, Gao Jian-Xin
Abstract excerpt
Cancer stem cells (CSCs) have been identified in hematopoietic and solid tumors. However, their precursors-namely, precancerous stem cells (pCSCs) -have not been characterized. Here we experimentally define the pCSCs that have the potential for both benign and malignant differentiation, depending...
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