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Article

Dysplastic Stem Cell Plasticity Functions as a Driving Force for Neoplastic Transformation of Precancerous Gastric Mucosa

11 Jun 2022

Abstract excerpt

Background & Aims Dysplasia carries a high risk of cancer development; however, the cellular mechanisms for dysplasia evolution to cancer are obscure. We have previously identified 2 putative dysplastic stem cell (DSC) populations, CD44v6 neg /CD133 + /CD166 + (double positive [DP]) and CD44v6 + /CD133 + /CD166 + (triple positive [TP]), which may contribute to cellular heterogeneity of gastric dysplasia. Here, we...

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PMID: 35700772
DOI: 10.1053/j.gastro.2022.06.021

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