Article
Precancer Atlas to Drive Precision Prevention Trials.
Cancer research - 1 Apr 2017
Spira Avrum, Yurgelun Matthew B, Alexandrov Ludmil, Rao Anjana, Bejar Rafael, Polyak Kornelia, Giannakis Marios, Shilatifard Ali, Finn Olivera J, Dhodapkar Madhav, Kay Neil E, Braggio Esteban, Vilar Eduardo, Mazzilli Sarah A, Rebbeck Timothy R, Garber Judy E, Velculescu Victor E, Disis Mary L, Wallace Douglas C, Lippman Scott M
Abstract excerpt
Cancer development is a complex process driven by inherited and acquired molecular and cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality will take a fundamental rethinking and deep understanding of premalignant biology. In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), integrating multi-omics and immunity - basic tenets...
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