Article

Single-Cell Transcriptomic Mapping of PD-L1/TLR4 Remodeling Informs Topical Immunoprevention Timing in Skin Carcinogenesis

2026-06-04

Abstract excerpt

Cutaneous squamous cell carcinoma (cSCC) represents a growing public health burden, with incidence projected to increase 23–29% over the coming decade. Topical immunoprevention strategies targeting the PD-L1 / PD-1 and TLR4 axes have demonstrated preclinical efficacy, yet optimal intervention timing in humans remains undefined. To address this gap, single-cell RNA sequencing was performed on matched sun-protect...

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Literature Corpus work: 763a24d0-b4d0-5d99-bb38-d5821eb57fba
DOI: 10.64898/2026.06.01.729458

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