Article

Integrative analysis of spatiotemporal transcriptomics delineates dynamic cell states in squamous tumorigenesis

2025-10-02

Abstract excerpt

<h4>SUMMARY</h4> Squamous cell cancers are responsible for 1 in 5 cancer deaths and survival improvements lag behind those seen in adenocarcinomas. This disparity is in large part due to the limited impact of immunotherapy due to therapeutic resistance, where less than ten percent of patients respond in early stage squamous cell carcinomas of the Head and Neck. Mechanisms that govern intrinsic resistance remain p...

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Literature Corpus work: f28e2d3c-61a6-5c8b-88f0-ff08c8a82f33
DOI: 10.1101/2025.09.30.679409

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