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Article

Human Pluripotent Stem Cells to Model Islet Defects in Diabetes.

Frontiers in endocrinology - 1 Jan 2021

Balboa Diego, Iworima Diepiriye G, Kieffer Timothy J

Abstract excerpt

Diabetes mellitus is characterized by elevated levels of blood glucose and is ultimately caused by insufficient insulin production from pancreatic beta cells. Different research models have been utilized to unravel the molecular mechanisms leading to the onset of diabetes. The generation of pancreatic endocrine cells from human pluripotent stem cells constitutes an approach to study genetic defects leading to...

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Identifiers

PMID: 33828531
DOI: 10.3389/fendo.2021.642152
PMCID: PMC8020750

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