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Sox9 regulates alternative splicing and pancreatic beta cell function

18 Jan 2024

Abstract excerpt

Despite significant research, mechanisms underlying the failure of islet beta cells that result in type 2 diabetes (T2D) are still under investigation. Here, we report that Sox9, a transcriptional regulator of pancreas development, also functions in mature beta cells. Our results show that Sox9-depleted rodent beta cells have defective insulin secretion, and aging animals develop glucose intolerance, mimicking...

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PMID: 38238288
DOI: 10.1038/s41467-023-44384-8

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