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Chromatin accessibility dynamics dictate renal tubular epithelial cell response to injury

28 Nov 2022

Abstract excerpt

Renal tubular epithelial cells (TECs) can initiate an adaptive response to completely recover from mild acute kidney injury (AKI), whereas severe injury often leads to persistence of maladaptive repair and progression to kidney fibrosis. Through profiling of active DNA regulatory elements by ATAC-seq, we reveal widespread, dynamic changes in the chromatin accessibility of TECs after ischemia-reperfusion injury....

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PMID: 36443310
DOI: 10.1038/s41467-022-34854-w

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