Article

Conserved transcriptional co-regulation of pyrophosphate homeostasis genes governs systemic mineralization factors in mice and humans

2025-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Inorganic pyrophosphate (PPi) is a critical inhibitor of ectopic calcification, yet transcriptional regulation of genes controlling its systemic production and degradation ( ABCC6 , ALPL , ANKH , ENPP1 ) remains elusive. We hypothesized that PPi homeostasis is governed by evolutionarily conserved transcription factor (TF) network. Promoter-motif analysis of PPi genes revealed conserved enric...

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Literature Corpus work: 92ceb218-1ff2-57d0-b35c-6d3ff66f6785
DOI: 10.1101/2025.09.21.677626

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