Article

Sexually dimorphic renal expression of Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b

2024-04-22

Abstract excerpt

<title>Abstract</title> <p>Transcription enhancers are genomic sequences regulating common and tissue-specific genes and their disruption can contribute to human disease development and progression. Klotho, a sexually dimorphic gene specifically expressed in kidney, is well-linked to kidney dysfunction and its deletion from the mouse genome leads to premature aging and death. However, the sexually dimorphic regul...

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Literature Corpus work: d80e5a75-336f-59bf-8808-cbca2d797b47
DOI: 10.21203/rs.3.rs-4188774/v1

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