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Mutation of Klotho rs3752472 protect the kidney from the renal epithelial cell injury caused by CaOx crystals through the Wnt/β-catenin signaling pathway.

Urolithiasis - 1 Dec 2021

Xu Chen, Zhang Wei, Lu Pei, Chen Jian-Chun, Zhou Yong-Qiang, Shen Gang, Wang Zhen-Fan, Ma Zheng, Jiang Min-Jun, Song Ri-Jin

Abstract excerpt

Calcium oxalate (CaOx) is a major contributor to urolithiasis, one of the most common urological diseases. Our previous study has shown that Klotho rs3752472 polymorphism correlates with an increased risk of CaOx-related urolithiasis in human cohorts. This study aims to identify the effect of Klotho rs3752472 polymorphism on the renal epithelium injury caused by CaOx. A rat urolithiasis model was established and...

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PMID: 34050772
DOI: 10.1007/s00240-021-01269-z

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