Article

Spatial Multiomics Analysis Identifies SOCS1 as a Key Immune Checkpoint in T cell Tolerance Induction of HSCT

2021-02-15

Abstract excerpt

<title>Abstract</title> <p>Achieving T cell tolerance ensures superior clinical outcomes in hematopoietic stem cell transplantation (HSCT). However, the <italic>in vivo</italic> T cell tolerance profiles in physiological state need to be further delineated. Here, we characterized the gene expression profile in tolerant T cells which was induced in healthy donors by granulocyte colony-stimulating factor, a stem ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c358b43-d11c-5e5c-87f6-35c6267768ed
DOI: 10.21203/rs.3.rs-150508/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial Multiomics Analysis Identifies SOCS1 as a Key Immune Checkpoint in T cell Tolerance Induction of HSCTDOI 10.21203/rs.3.rs-150508/v1Read

Three-dimensional genome structure and chromatin accessibility reorganization during <i>in vivo</i> induction of human T cell toleranceSemantic proximity Read

Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical TransplantationSemantic proximity Read

Single-cell Landscape Analysis Unravels Molecular Programming of the Human B Cell Compartment in Chronic GVHDSemantic proximity Read

Single-cell transcriptomics of allo-reactive CD4 <sup>+</sup> T cells over time reveals divergent fates during gut GVHDSemantic proximity Read

TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunitySemantic proximity Read

RNA-seq of Human T-Cells After Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Novel Regulator of T-Cell AlloimmunitySemantic proximity Read

STAT3 Role in T-Cell Memory FormationSemantic proximity Read

Methylation status of SOCS1 and SOCS3 genes in patients with acute lymphoid leukemia: A case-control studySemantic proximity Read

SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cellsSemantic proximity Read

One gene to rule them all – clinical perspectives of a potent suppressor of cytokine signaling – SOCS1Semantic proximity Read

The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host diseaseSemantic proximity Read

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screensSemantic proximity Read