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Article

One gene to rule them all – clinical perspectives of a potent suppressor of cytokine signaling – SOCS1

22 Apr 2024

Abstract excerpt

The discovery of Suppressor of Cytokine Signaling 1 (SOCS1) in 1997 marked a significant milestone in understanding the regulation of Janus kinase/Signal transducer and activator of transcription (JAK/STAT) signaling pathways. Subsequent research deciphered its cellular functions, and recent insights into SOCS1 deficiencies in humans underscored its critical role in immune regulation. In humans,...

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PMID: 38711523
DOI: 10.3389/fimmu.2024.1385190

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