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Article

The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host disease

8 Sept 2022

Abstract excerpt

Graft-versus-host disease (GVHD), manifesting as either acute (aGVHD) or chronic (cGVHD), presents significant life-threatening complications following allogeneic hematopoietic cell transplantation. Here, we investigated Friend virus leukemia integration 1 (Fli-1) in GVHD pathogenesis and validated Fli-1 as a therapeutic target. Using genetic approaches, we found that Fli-1 dynamically regulated different T cell...

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PMID: 36074578
DOI: 10.1172/jci143950

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