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Article

Causal relationship between Interleukin-27 expression levels and osteoporosis: a bidirectional mendelian randomization study.

BMC musculoskeletal disorders - 29 Aug 2024

Xue Yun, Zhou You, Li Chunyan, Zhang Jingshuang, Liu Fei, Shi Rui

Abstract excerpt

BACKGROUND: This study aimed to evaluate the causal relationship between Interleukin-27 (IL-27) and osteoporosis by bidirectional Mendelian randomization (MR) analysis. METHODS: Firstly, the genome-wide association study summary data of osteoporosis (finn-b-M13_OSTEOPOROSIS) and IL-27 levels (ebi-a-GCST90012017) were picked out from the Integrative Epidemiology Unit (IEU) OpenGWAS database. After filtrating...

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Source

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Identifiers

PMID: 39210324
DOI: 10.1186/s12891-024-07765-8
PMCID: PMC11363690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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