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Article

Osteoporosis and osteoarthritis: a bi-directional Mendelian randomization study.

Arthritis research & therapy - 13 Dec 2023

Qu Yudun, Chen Shibo, Han Mengling, Gu Ziqi, Zhang Yujie, Fan Tianxiang, Zeng Muhui, Ruan Guangfeng, Cao Peihua, Yang Qian, Ding Changhai, Zhang Yan, Zhu Zhaohua

Abstract excerpt

OBJECTIVE: To investigate the causal relationship between low bone mineral density (BMD) and osteoarthritis (OA) using Mendelian randomization (MR) design. METHODS: Two-sample bi-directional MR analyses were performed using summary-level information on OA traits from UK Biobank and arcOGEN. Sensitivity analyses including MR-Egger, simple median, weighted median, MR pleiotropy residual sum, and outlier approaches...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38093316
DOI: 10.1186/s13075-023-03213-5
PMCID: PMC10717893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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