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Article

The causal role of circulating inflammatory markers in osteoporosis: a bidirectional Mendelian randomized study.

Frontiers in immunology - 1 Jan 2024

Dong Qiu, Wu Jiayang, Zhang Huaguo, Luo Liangping, Wu Wenrui

Abstract excerpt

Background: Osteoporosis (OP) associated with aging exerts substantial clinical and fiscal strains on societal structures. An increasing number of research studies have suggested a bidirectional relationship between circulating inflammatory markers (CIMs) and OP. However, observational studies are susceptible to perturbations in confounding variables. In contrast, Mendelian randomization (MR) offers a robust...

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Bayes Theorem
Biomarkers
Genetic Predisposition to Disease
Genome-Wide Association Study
Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39091505
DOI: 10.3389/fimmu.2024.1412298
PMCID: PMC11291241

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