Article

SF3B1-targeted Splicing Inhibition Triggers Transcriptional Stress Response and Global Alterations in R-Loop Landscape

2020-06-08

Abstract excerpt

<h4>SUMMARY</h4> Efficient co-transcriptional splicing is thought to suppress genome-destabilizing R-loops. Inhibition of SF3B1, a core U2 spliceosome component, by Pladienolide B (PladB) in human K562 cells caused widespread intron retention and modest R-loops gains. Minimal overlap existed between these events, suggesting that unspliced introns by themselves do not cause excessive R-loops. R-loop gains were ins...

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Literature Corpus work: 6c13a3c7-6e72-5a17-8cb9-3c4aedc94d14
DOI: 10.1101/2020.06.08.130583

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