Article

Dysregulated Spliceosome Activity Involves Increased Intron Retention Plus Upregulation and Phosphorylation of SF3B1 in Chronic Lymphocytic Leukemia

2022-05-11

Abstract excerpt

<h4>Background: </h4> Alternative splicing (AS) is a fundamental process in eukaryotes contributing to the diversity of mRNA isoforms with variable ratios of intron/exon. SF3B1 is a pivotal protein of the spliceosome machinery. Mutations in the SF3B1 gene have prognostic value in Chronic Lymphocytic Leukemia (CLL). Our previous studies have shown that SF3B1 inhibition with macrolides induces apoptosis specifically...

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Literature Corpus work: 869eb297-4043-5739-a4dc-c96b759ed7ae
DOI: 10.21203/rs.3.rs-1622375/v1

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