Article
Introns Protect Eukaryotic Genomes from Transcription-Associated Genetic Instability.
Molecular cell - 17 Aug 2017
Bonnet Amandine, Grosso Ana R, Elkaoutari Abdessamad, Coleno Emeline, Presle Adrien, Sridhara Sreerama C, Janbon Guilhem, Géli Vincent, de Almeida Sérgio F, Palancade Benoit
Abstract excerpt
Transcription is a source of genetic instability that can notably result from the formation of genotoxic DNA:RNA hybrids, or R-loops, between the nascent mRNA and its template. Here we report an unexpected function for introns in counteracting R-loop accumulation in eukaryotic genomes. Deletion of endogenous introns increases R-loop formation, while insertion of an intron into an intronless gene suppresses R-loop...
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