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Article

Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies.

Molecular cell - 17 Mar 2022

Biancon Giulia, Joshi Poorval, Zimmer Joshua T, Hunck Torben, Gao Yimeng, Lessard Mark D, Courchaine Edward, Barentine Andrew E S, Machyna Martin, Botti Valentina, Qin Ashley, Gbyli Rana, Patel Amisha, Song Yuanbin, Kiefer Lea, Viero Gabriella, Neuenkirchen Nils, Lin Haifan, Bewersdorf Joerg, Simon Matthew D, Neugebauer Karla M, Tebaldi Toma, Halene Stephanie

Abstract excerpt

Splicing factor mutations are common among cancers, recently emerging as drivers of myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however, how they affect splicing and promote cancer remain unclear. The U2AF1/U2AF2 heterodimer is critical for 3' splice site (3'SS) definition. To specifically unmask changes in U2AF1 function in vivo, we developed a crosslinking and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35303483
DOI: 10.1016/j.molcel.2022.02.025
PMCID: PMC8988922

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