Article

An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys

2018-03-09

Abstract excerpt

During terminal erythropoiesis, the splicing machinery in differentiating erythroblasts executes a robust intron retention (IR) program that impacts expression of hundreds of genes. We studied IR mechanisms in the SF3B1 splicing factor gene, which expresses ~50% of its transcripts in late erythroblasts as a nuclear isoform that retains intron 4. RNA-seq analysis of nonsense-mediated decay (NMD)-inhibited cells rev...

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Literature Corpus work: 46bbaaf4-6680-5f27-80ca-c9d57cc12e07
DOI: 10.1101/258897

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