Article

Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and psychiatric disease

2023-08-17

Abstract excerpt

<h4>ABSTRACT</h4> The dopamine transporter (DAT) plays a crucial role in regulating the brain’s dopamine (DA) homeostasis. Atypical DAT deficiency syndrome (DTSD) is a disease characterized by early-onset parkinsonism and comorbid psychiatric symptoms, but the pathobiological processes that link DAT dysfunction to both parkinsonism and psychiatric symptoms are unknown. Here, we present a genetic mouse model of at...

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Literature Corpus work: caf88576-045c-5acc-b292-d4c7d837ea94
DOI: 10.1101/2023.08.17.553695

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