Article

Head-on replication-transcription collisions lead to formation of life threatening R-loops

2017-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Encounters between transcription and DNA replication machineries lead to conflicts that shape genomes, influence evolution, and lead to genetic diseases in humans. Although unclear why, head-on transcription (lagging strand genes) is especially disruptive to replication, increases DNA breaks, and promotes mutagenesis. Here, we show that head-on replication-transcription conflicts lead to pervasi...

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Literature Corpus work: 6c054361-6d9f-5b5d-a6ff-0ab68522a775
DOI: 10.1101/154427

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