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Article

The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo.

The EMBO journal - 6 Jan 2010

Boubakri Hasna, de Septenville Anne Langlois, Viguera Enrique, Michel Bénédicte

Abstract excerpt

How living cells deal with head-on collisions of the replication and transcription complexes has been debated for a long time. Even in the widely studied model bacteria Escherichia coli, the enzymes that take care of such collisions are still unknown. We report here that in vivo, the DinG, Rep and UvrD helicases are essential for efficient replication across highly transcribed regions. We show that when rRNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19851282
DOI: 10.1038/emboj.2009.308
PMCID: PMC2770101

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Source receipt: pubmed, retrieved 7 Sept 2026.

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