Article

NG2 glia protect against prion neurotoxicity by inhibiting prostaglandin E2 signaling

2023-04-04

Abstract excerpt

Oligodendrocyte-lineage cells, including NG2 glia, undergo prominent changes in various neurodegenerative disorders. This raises the question of how myelinating cells interact with neurodegenerative processes. Here, we found that NG2 glia were activated after prion infection in cerebellar organotypic cultured slices (COCS) and in brains of prion-inoculated mice. In both model systems, depletion of NG2 glia exacerb...

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Literature Corpus work: 6c03eace-af0a-525b-80ed-1cd345459f51
DOI: 10.1101/2023.04.04.535590

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