Article

Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain

2021-02-18

Abstract excerpt

Doublecortin (DCX) is a microtubule (MT) associated protein that regulates MT structure and function during neuronal development and mutations in DCX lead to a spectrum of neurological disorders. The structural properties of MT-bound DCX remain poorly resolved. Here, we describe the molecular architecture of the DCX-MT complex through an integrative modeling approach that combines data from X-ray crystallography,...

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Literature Corpus work: 6bf8b1ad-7aba-58ad-aac4-2d8fb78e2016
DOI: 10.1101/2021.02.17.431714

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