Article

Doublecortin restricts neuronal branching by regulating tubulin polyglutamylation

2023-06-03

Abstract excerpt

Doublecortin (DCX) is a neuronal microtubule-associated protein (MAP) that binds directly to microtubules via two Doublecortin (DC) domains. The DC domains sense the nucleotide state, longitudinal curvature, and protofilament number of the microtubule lattice, indicating a role in the regulation of microtubule structure in neurons. Mutations in DCX cause lissencephaly and subcortical band heterotopia (also known a...

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Literature Corpus work: bf783770-ef16-5236-b27d-12792495450a
DOI: 10.1101/2023.06.02.543327

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