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Article

[Research progress on the pathogenesis mechanism and therapeutic strategies of DCX mutants].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 10 Jan 2026

Sun Xuyan, Li Bei, Zhao Siyu, Li Xia

Abstract excerpt

The doublecortin (DCX) gene encodes DCX, a microtubule-associated protein that plays a crucial role in brain development. DCX variants can disrupt microtubule binding and stabilization, interfere with intracellular transport, and affect post-translational modifications. A correlation exists between variant types and clinical severity. Animal models and induced pluripotent stem cell (iPSC) models simulating DCX...

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Identifiers

PMID: 41621848
DOI: 10.3760/cma.j.cn511374-20250926-00575

Genes

DCX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Research trail→

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[Research progress on the pathogenesis mechanism and therapeutic strategies of DCX mutants].PMID 41621848Read ↗

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Phenotypic Variability in Novel Doublecortin Gene Variants Associated with Subcortical Band Heterotopia.Semantic proximity Read ↗

Mitotic impairment by doublecortin is diminished by doublecortin mutations found in patients.Semantic proximity Read ↗

[Analysis of DCX gene mutation in a patient featuring X-linked subcortical laminar heterotopia and epilepsy].Semantic proximity Read ↗

DDX3X syndrome: From clinical phenotypes to biological insights.Semantic proximity Read ↗

Doublecortin restricts neuronal branching by regulating tubulin polyglutamylationSemantic proximity Read ↗

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