Article
The DCX-domain tandems of doublecortin and doublecortin-like kinase.
Nature structural biology - 1 May 2003
Kim Myung Hee, Cierpicki Tomasz, Derewenda Urszula, Krowarsch Daniel, Feng Yuanyi, Devedjiev Yancho, Dauter Zbigniew, Walsh Christopher A, Otlewski Jacek, Bushweller John H, Derewenda Zygmunt S
Abstract excerpt
The doublecortin-like domains (DCX), which typically occur in tandem, are novel microtubule-binding modules. DCX tandems are found in doublecortin, a 360-residue protein expressed in migrating neurons; the doublecortin-like kinase (DCLK); the product of the RP1 gene that is responsible for a form of inherited blindness; and several other proteins. Mutations in the gene encoding doublecortin cause lissencephaly in...
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