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Article

Mitotic impairment by doublecortin is diminished by doublecortin mutations found in patients.

Neurogenetics - 1 Jun 2004

Couillard-Despres Sebastien, Uyanik Goekhan, Ploetz Sonja, Karl Claudia, Koch Hartmut, Winkler Juergen, Aigner Ludwig

Abstract excerpt

Mutations in doublecortin ( DCX) affect the migration of neuronal precursor cells and cause subcortical band heterotopia and lissencephaly. DCX is known to bind and bundle microtubules; however, the impact of mutation on DCX function and its relation to the manifestation of DCX-associated disorders is still unclear. We analyzed the impact of DCX mutants on COS7 cell microtubule networks. We found that both mutant...

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Identifiers

PMID: 15045646
DOI: 10.1007/s10048-004-0176-1

Genes

DCX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitotic impairment by doublecortin is diminished by doublecortin mutations found in patients.PMID 15045646Read ↗

Doublecortin restricts neuronal branching by regulating tubulin polyglutamylationSemantic proximity Read ↗

Doublecortin mutations cluster in evolutionarily conserved functional domains.Semantic proximity Read ↗

Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell MobilitySemantic proximity Read ↗

Doublecortin reinforces microtubules to promote growth cone advance in soft environmentsSemantic proximity Read ↗

Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites.Semantic proximity Read ↗

Different Doublecortin (DCX) Patient Alleles Show Distinct Phenotypes in Cultured Neurons: EVIDENCE FOR DIVERGENT LOSS-OF-FUNCTION AND "OFF-PATHWAY" CELLULAR MECHANISMS.Semantic proximity Read ↗

Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.Semantic proximity Read ↗

New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum.Semantic proximity Read ↗

Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domainSemantic proximity Read ↗

The DCX-domain tandems of doublecortin and doublecortin-like kinase.Semantic proximity Read ↗

[Research progress on the pathogenesis mechanism and therapeutic strategies of DCX mutants].Semantic proximity Read ↗

A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies.Semantic proximity Read ↗

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