Article

Doublecortin reinforces microtubules to promote growth cone advance in soft environments

2024-02-29

Abstract excerpt

Doublecortin (DCX) is a microtubule-associated protein critical for brain development. Although most highly expressed in the developing central nervous system, the molecular function of DCX in neuron morphogenesis remains unknown and controversial. We demonstrate that DCX function is intimately linked to its microtubule-binding activity. By using human induced pluripotent stem cell (hiPSC)- derived cortical i 3 N...

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Literature Corpus work: 3a693e24-a940-51bb-814f-49ba413c269c
DOI: 10.1101/2024.02.28.582626

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