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Article

Native DGC structure rationalizes muscular dystrophy-causing mutations.

Nature - 1 Jan 2025

Liu Shiheng, Su Tiantian, Xia Xian, Zhou Z Hong

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder marked by progressive muscle wasting leading to premature mortality1,2. Discovery of the DMD gene encoding dystrophin both revealed the cause of DMD and helped identify a family of at least ten dystrophin-associated proteins at the muscle cell membrane, collectively forming the dystrophin-glycoprotein complex (DGC)3-9. The DGC links the...

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Identifiers

PMID: 39663457
DOI: 10.1038/s41586-024-08324-w
PMCID: PMC11936492

Genes

DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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