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Article

Domain swap in the C-terminal ubiquitin-like domain of human doublecortin.

Acta crystallographica. Section D, Structural biology - 1 May 2018

Rufer Arne C, Kusznir Eric, Burger Dominique, Stihle Martine, Ruf Armin, Rudolph Markus G

Abstract excerpt

Doublecortin, a microtubule-associated protein that is only produced during neurogenesis, cooperatively binds to microtubules and stimulates microtubule polymerization and cross-linking by unknown mechanisms. A domain swap is observed in the crystal structure of the C-terminal domain of doublecortin. As determined by analytical ultracentrifugation, an open conformation is also present in solution. At higher...

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Identifiers

PMID: 29717716
DOI: 10.1107/S2059798318004813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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