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CRISPRi Screening Identifies SON and MAP4K1 as Regulators of Type III Cytokine Expression in Innate Lymphoid Cells

2025-08-15

Abstract excerpt

<h4>ABSTRACT</h4> The cytokines interleukin (IL)-22 and IL-17 are secreted by innate and adaptive immune cells to drive “type III” responses that protect against extracellular pathogens, promote mucosal barrier integrity, and foster microbiota homeostasis. However, dysregulation of IL-22 and/or IL-17 contributes to autoimmunity, chronic inflammation, and malignancy. Thus, a deeper understanding of mechanisms regu...

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Literature Corpus work
6be0a467-1223-5e0b-ab19-e01af9ebb195
DOI
10.1101/2025.08.15.670561
Open publication

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CRISPRi Screening Identifies SON and MAP4K1 as Regulators of Type III Cytokine Expression in Innate Lymphoid CellsDOI 10.1101/2025.08.15.670561
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