Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma

7 Dec 2022

Abstract excerpt

Epithelial responses to the cytokine interleukin-13 (IL-13) cause airway obstruction in asthma. Here we utilized multiple genomic techniques to identify IL-13-responsive regulatory elements in bronchial epithelial cells and used these data to develop a CRISPR interference (CRISPRi)-based therapeutic approach to downregulate airway obstruction-inducing genes in a cell type- and IL-13-specific manner. Using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to IL-33, ST2, and ILC Pathways
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36777184
DOI: 10.1016/j.xgen.2022.100229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthmaPMID 36777184Read ↗

Targeting a central feature of asthma using a cell type-selective IL-13-responsive enhancerSemantic proximity Read ↗

CRISPRi Screening Identifies SON and MAP4K1 as Regulators of Type III Cytokine Expression in Innate Lymphoid CellsSemantic proximity Read ↗

Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High AsthmaSemantic proximity Read ↗

Bidirectional epigenetic editing reveals hierarchies in gene regulationSemantic proximity Read ↗

Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screensSemantic proximity Read ↗

Rescue of STAT3 Function in Hyper-IgE Syndrome Using Adenine Base Editing.Semantic proximity Read ↗

CRISPR activation and interference screens in primary human T cells decode cytokine regulationSemantic proximity Read ↗

Identification of Functional Variants in the FAM13A Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Locus by Massively Parallel Reporter Assays.Semantic proximity Read ↗

Efficient RNP-directed human gene targeting reveals SPDEF is required for IL-13-induced mucostasisSemantic proximity Read ↗

Genetic, inflammatory, and epithelial cell differentiation factors control expression of human calpain-14Semantic proximity Read ↗

A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.Semantic proximity Read ↗

An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.