Article

Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling

2021-01-26

Abstract excerpt

<h4>Summary</h4> The cytokine receptor IL-23R plays a fundamental role in inflammation and autoimmunity. However, several observations have been difficult to reconcile under the assumption that only Th17 cells critically depend on IL-23 to acquire a pathogenic phenotype. Here, we report that Th1 cells differentiated in vitro with IL-12 + IL-21 show similar levels of IL-23R expression as in pathogenic Th17 cells....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d6de932-f997-583c-bc8f-f4ddd2637a99
DOI: 10.1101/2021.01.24.426445

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signalingDOI 10.1101/2021.01.24.426445Read

Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling.Semantic proximity Read

IL-23 Licenses Pathogenic Th17 Transdifferentiation via STAT4-dependent Upregulation of IL-12Rβ2Semantic proximity Read

IL-23 tunes inflammatory functions of human mucosal-associated invariant T (MAIT) cellsSemantic proximity Read

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23Semantic proximity Read

DNAM-1 immunoreceptor integrates innate and adaptive immune programs to drive intestinal inflammationSemantic proximity Read

CRISPRi Screening Identifies SON and MAP4K1 as Regulators of Type III Cytokine Expression in Innate Lymphoid CellsSemantic proximity Read

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease.Semantic proximity Read

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunitySemantic proximity Read

Targeting the IL-23 Receptor Gene: A Promising Approach in Inflammatory Bowel Disease TreatmentSemantic proximity Read

Expression of miRNAs miR-133b and miR-206 in the Il17a/f Locus Is Co-Regulated with IL-17 Production in αβ and γδ T CellsSemantic proximity Read

Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease.Semantic proximity Read

The regulatory mechanism and potential application of IL-23 in autoimmune diseasesSemantic proximity Read