Back to search

Article

IL-23 tunes inflammatory functions of human mucosal-associated invariant T (MAIT) cells

2024-08-30

Abstract excerpt

<h4>Summary</h4> IL-23 signaling plays a key role in the pathogenesis of chronic inflammatory and infectious diseases, yet the cellular targets and signaling pathways affected by this cytokine remain poorly understood. We show that IL-23 receptors are expressed on the large majority of human MAIT, but not of conventional T cells. Protein and transcriptional profiling at the population and single cell level demons...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4cfcdca4-7059-57f0-9e46-8adf5cafc13b
DOI
10.1101/2024.08.29.609178
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
IL-23 tunes inflammatory functions of human mucosal-associated invariant T (MAIT) cellsDOI 10.1101/2024.08.29.609178
IL-23 Licenses Pathogenic Th17 Transdifferentiation via STAT4-dependent Upregulation of IL-12Rβ2Semantic proximity
Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signalingSemantic proximity
CRISPRi Screening Identifies SON and MAP4K1 as Regulators of Type III Cytokine Expression in Innate Lymphoid CellsSemantic proximity
Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activationSemantic proximity
A single-cell atlas of IL-23 inhibition in cutaneous psoriasis distinguishes clinical responseSemantic proximity
Interleukin-17 producing mucosal associated invariant T cells - emerging players in chronic inflammatory diseases?Semantic proximity
IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis.Semantic proximity
The regulatory mechanism and potential application of IL-23 in autoimmune diseasesSemantic proximity
Insights into IL-23 biology: From structure to functionSemantic proximity
DNAM-1 immunoreceptor integrates innate and adaptive immune programs to drive intestinal inflammationSemantic proximity
A genome-wide innateness gradient defines the functional state of human innate T cellsSemantic proximity
The Dichotomous Pattern of IL-12R and IL-23R Expression Elucidates the Role of IL-12 and IL-23 in InflammationSemantic proximity
Select a neighboring publication to make it the new centre.