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Article

IL-23 Licenses Pathogenic Th17 Transdifferentiation via STAT4-dependent Upregulation of IL-12Rβ2

2026-07-26

Abstract excerpt

Th17 cells exhibit substantial developmental plasticity, transdifferentiating into pathogenic, interferon-γ (IFN-γ)–producing Th1-like effectors during chronic autoimmune inflammation. While both IL-23 and IL-12 are implicated in this process, how these structurally related cytokines coordinate to drive transdifferentiation remains unresolved. Here, we show that IL-23 acts as a developmental licensor rather than a...

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Identifiers and source

Literature Corpus work
43905e46-c7e9-5d35-ae1e-b0d5f6d317a9
DOI
10.64898/2026.07.23.740320
Open publication

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IL-23 Licenses Pathogenic Th17 Transdifferentiation via STAT4-dependent Upregulation of IL-12Rβ2DOI 10.64898/2026.07.23.740320
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